The HPE ProLiant DL385 Gen10 Plus Server is redefining price/performance with the new math for virtualized compute.

What’s New:

  • Supports the latest AMD EPYC 7002 Series processor with double the core density compared to the previous generation and increased memory speeds up to 3200 MT/s.
  • Support for PCIe Gen4, resulting in improved networking speeds.
  • Support for OCP Network Adapters.
  • New SATA Read Intensive SSD drives.
  • New NVMe Read Intensive and Mixed Use SSD drives.
  • Support for PCIe Smart Array controllers for internal and external drives.
  • European Union (EU) Lot 9 regulation, please visit: https://www.hpe.com/us/en/about/environment/msds-specs-more.html for more information

Platform Information

Form Factor

  • 2U rack

Chassis Types

  • 8 SFF with optional Universal Media Bay, and optional SFF or NVMe drive bay options
  • 24 SFF bay with 8 SFF mid tray drives and 6 SFF rear drive bay option to total 38 SFF drives
  • 8 LFF with Universal Media Bay, and optional SFF or NVMe drive bay options
  • 12 LFF with optional 4 LFF mid-plane and optional 4 LFF to total 20 LFF drives


  • The 4 LFF rear drive box will consume space for the primary and secondary riser.
  • The 8 and 12 LFF chassis also supports the 2 SFF rear drive box which allows for the user to attach a secondary or tertiary riser.
  • The 8 NVMe drive option (P14578-B21) can only be leveraged in the SFF chassis and replaces Box 1, 2 or 3.
  • The Universal Media Bay (P14609-B21) not available with the LFF chassis or the 24 SFF front, and can only be populated in Box 1.
  • The 8 NVMe SFF can be upgraded with additional two front 8 NVMe SFF drive boxes (P14578-B21) to total 24 SFF NVMe drives, and up to 32 SFF NVMe drives with one mid 8 NVMe SFF drive cage (P14601-B21).
  • The 8 LFF chassis cannot be upgraded to 12 LFF front in the field.
  • 12 LFF or more drives require Max performance fan kit (P14608-B21).
  • The 8 LFF chassis ships with 6 standard fans.
  • CPU selection is limited 200W or lower with 4LFF mid-tray selected & DIMM blanks populate empty DIMM slots.
  • If CPU power is >180W then it is required to use 2U Performance Heat sink.

System Fans

Standard – fan types included

  • On SFF Chassis only, 1P models ship with 4 standard fans. The second processor option kit contains 2 additional fans.
  • The 12 LFF and 24 SFF chassis ship with 6 Max performance fans as standard.
  • The 8 LFF chassis ships with 6 standard fans as standard.
  • Max performance fan kit is available to meet ambient temperature environments.
  • Max performance fan kits are required for rear drives, or >180w Processors SKUs, or if High Performance NVMe drive being used.
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